Response: HIV-1 Evolution and Disease Progression
نویسندگان
چکیده
منابع مشابه
HIV-1 evolution and disease progression.
REFERENCES AND NOTES se that destroys the host. Thus, within a particular host, diversity is driven by the collective sum of all the selective forces acting on the HIV-1 quasispecies virus population, rather than a specific immune parameter by or in itself (4). The theory predicts two possible outcomes. First, infected individuals with diversity higher than their individual specific threshold l...
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Quantifying the dynamics of intrahost HIV-1 sequence evolution is one means of uncovering information about the interaction between HIV-1 and the host immune system. In the chronic phase of infection, common dynamics of sequence divergence and diversity have been reported. We developed an HIV-1 sequence evolution model that simulated the effects of mutation and fitness of sequence variants. The...
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In the past five years, the HIV research field has shown renewed interest in the replicative capacity of human immunodeficiency virus type 1 (HIV-1) due to the potential impact of ex vivo viral fitness on population size (viral load), drug resistance, and disease progression. For example, studies on HIV-1 fitness of drug-resistant mutants under different selective pressures have led to a better...
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Reports from the United States have demonstrated that elevated markers of microbial translocation from the gut may be found in chronic and advanced HIV-1 infection and are associated with an increase in immune activation. However, this phenomenon's role in HIV-1 disease in Africa is unknown. This study examined the longitudinal relationship between microbial translocation and circulating inflam...
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ژورنال
عنوان ژورنال: Science
سال: 1996
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.274.5289.1010